API

Mechanism of Action

Vonoprazan fumarate is a proton pump inhibitor that works by reducing the amount of acid produced in the stomach. It does this by blocking the activity of the enzyme H+/K+ ATPase, which is responsible for producing gastric acid.

The mechanism of action of vonoprazan fumarate involves the inhibition of the final step of acid secretion, which is the transport of hydrogen ions into the gastric lumen. This leads to a decrease in the production of gastric acid and therefore reduces the amount of acid that is available to cause damage to the esophagus, stomach, or duodenum.

Vonoprazan fumarate has a rapid onset of action and provides sustained acid suppression for 24 hours with a single daily dose, making it an effective treatment for a variety of acid-related conditions such as gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), and Zollinger-Ellison syndrome.

Indication

Vonoprazan fumarate is indicated for the treatment of various acid-related conditions, including:

Gastroesophageal Reflux Disease (GERD): Vonoprazan fumarate is used to relieve symptoms of GERD, such as heartburn, regurgitation, and chest pain.

Peptic Ulcer Disease (PUD): Vonoprazan fumarate is used to treat PUD, which is caused by the formation of sores or ulcers in the stomach or duodenum.

Zollinger-Ellison Syndrome: Vonoprazan fumarate is used to treat Zollinger-Ellison syndrome, a rare condition in which the stomach produces too much acid.

It is important to note that vonoprazan fumarate should be used only under the supervision of a healthcare provider, and the dose and duration of treatment should be based on the individual's medical condition and response to therapy.