About Pantoprazole Sodium API
Therapeutic CategoryGastro-Intestinal - GI
CAS Number
164579-32-2
API Technology
Synthetic
Dose Form
Suspension, Tablets, Injectable
Dr Reddy's Development Status
Available
Available Regulatory Filing
USDMF, CEP Submitted, Brazil DMF, EUDMF, Canada DMF, Japan DMF, China DMF
Mechanism of Action
Pantoprazole is a PPI that suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours for all doses tested (20 mg to 120 mg).
Indication
PROTONIX is a proton pump inhibitor (PPI) indicated for the following:
- Short-Term Treatment of Erosive Esophagitis Associated with Gastroesophageal Reflux Disease (GERD)
- Maintenance of Healing of Erosive Esophagitis
- Pathological Hypersecretory Conditions Including Zollinger-Ellison (ZE) Syndrome
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