API

Mechanism of Action

Cabozantinib is a tyrosine kinase inhibitor that acts by blocking the activity of multiple tyrosine kinases, including MET and VEGFR2. Tyrosine kinases are enzymes that play a key role in signaling pathways that regulate cellular processes such as proliferation, migration, and angiogenesis.

In cancer, these signaling pathways are often dysregulated, leading to uncontrolled cell growth and survival. By inhibiting the activity of these kinases, cabozantinib can block these signaling pathways and potentially slow or stop the growth of cancer cells.

Specifically, cabozantinib has been shown to effectively inhibit the activity of MET, a tyrosine kinase that is overexpressed in many cancers and plays a key role in tumor growth, invasion, and angiogenesis. Inhibition of VEGFR2, another target of cabozantinib, can also block the growth of new blood vessels that tumors need to grow and spread.

Overall, the mechanism of action of cabozantinib involves blocking the activity of multiple tyrosine kinases involved in cancer cell growth and survival, ultimately leading to the inhibition of tumor growth.

Indication

Cabozantinib is an FDA-approved treatment for several types of cancer. It is indicated for the following indications:

Metastatic Renal Cell Carcinoma (mRCC): Cabozantinib is indicated for the treatment of patients with advanced or metastatic renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy.

Medullary Thyroid Cancer (MTC): Cabozantinib is indicated for the treatment of patients with locally advanced or metastatic medullary thyroid cancer (MTC) who require systemic therapy and have received prior treatment with radioactive iodine.

Hormone-Relapsed Prostate Cancer: Cabozantinib is indicated for the treatment of patients with hormone-relapsed prostate cancer that has progressed during or after androgen deprivation therapy.

Advanced Liver Cancer: Cabozantinib is indicated for the treatment of patients with hepatocellular carcinoma who have been previously treated with sorafenib.