API

Mechanism of Action

Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. The S-and R-isomers of omeprazole are protonated and converted in the acidic compartment of the parietal cell forming the active inhibitor, the achiral sulphenamide. By acting specifically on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric acidity. This effect is dose-related up to a daily dose of 20 to 40 mg and leads to inhibition of gastric acid secretion.

Indication

NEXIUM is a proton pump inhibitor indicated for the following:

• Treatment of gastroesophageal reflux disease (GERD)
• Risk reduction of NSAID-associated gastric ulcer.
• H. pylori eradication to reduce the risk of duodenal ulcer recurrence.
• Pathological hypersecretory conditions, including Zollinger-Ellison syndrome.