API

Mechanism of Action

Tafamidis free acid is a transthyretin stabilizer. It works by binding to the thyroxine-binding sites of transthyretin tetramers, stabilizing them and reducing the dissociation into monomers, which prevents amyloid formation

Indication

Tafamidis free acid is indicated for the treatment of cardiomyopathy caused by wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM) in adults, to reduce cardiovascular mortality and cardiovascular-related hospitalization